Cyclophosphamide
has action leading to cross-linking of RNA of tumor cells, and
thereby interferes with the growth of susceptible rapidly proliferating
malignant cells. It is effective against a range of cancers, such
as malignant lymphomas, Hodgkin’s disease, various leukemias,
and cancer of the breast and ovaries. This drug is toxic, with
side effects including nausea, vomiting, anorexia, diarrhea, skin
rash and darkening and, in extreme cases, heart damage or failure,
and secondary malignancies. It is manufactured by Bristol-Myers-Squibb
Company under the brand name Cytoxan® for intravenous and
oral administration. We believe that there are no patents covering
the composition of cyclophosphamide.
